| 研究概要 |
■ 研究概要
◆研究課題
哺乳動物の胚発生と老化機構の解析
◆研究概要
胚発生における左右軸形成機構、アミノ酸代謝が支配する胚発生や老化機構には、まだまだ不明なことが多い。本研究では、腎臓や肝臓など左右非対称に形成される器官の形成機構を解析する。さらに、形態的に左右非対称に形成される肝臓において、機能的な左右差もあるのかどうか解析する。また、胚発生や老化に関与するアミノ酸代謝経路の役割を明らかにする。
具体的には、以下の内容について研究を進める。
・腎臓や肝臓が左右非対称に形成されるしくみ
・生殖器と胚発生における細胞外マトリックス因子の役割
・肝臓の機能的な左右差の解析
・毛包の形成と維持におけるアミノ酸合成酵素の役割
・血糖調節におけるアミノ酸合成酵素の役割
・胚発生におけるアミノ酸代謝酵素の役割 |
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| 業績 |
■ 学会発表
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■ 著書・論文歴
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1. |
2022/05 |
論文 |
Planar cell polarity-dependent asymmetric organization of microtubules for polarized positioning of the basal body in node cells. Development 149(9),dev200315頁 （共著） |
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2. |
2020/12 |
論文 |
CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components （共著） |
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3. |
2020/11 |
論文 |
CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module Nature Communications （共著） |
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4. |
2020/07 |
論文 |
Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2 Neuron （共著） |
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5. |
2020/07 |
論文 |
Role of Ca 2+ transients at the node of the mouse embryo in breaking of left-right symmetry Science Advances （共著） |
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6. |
2018/08 |
論文 |
Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters. Elife. 7,pp.pii: e36435 （共著） |
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7. |
2017/03 |
論文 |
A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking. Dev Cell. 40(5),pp.439-452 （共著） |
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8. |
2016/08 |
論文 |
TTC25 Deficiency Results in Defects of the Outer Dynein Arm Docking Machinery and Primary Ciliary Dyskinesia with Left-Right Body Asymmetry Randomization. Am J Hum Genet. 99(2),pp.460-469 （共著） |
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9. |
2015/10 |
論文 |
Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo. PLoS One. 10(10),pp.e0140831 （共著） |
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10. |
2014 |
論文 |
Pih1d3 is required for cytoplasmiccytoplasmic pre-assembly of axonemal dyneins in mouse sperm. J Cell Biol. 204(2),pp.203-13 |
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11. |
2014 |
論文 |
Self-regulated left-right asymmetric expression of Pitx2c in the developing mouse limb. Dev Biol. 395(2),pp.331-41 |
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12. |
2014 |
論文 |
TGFβ signaling in establishing left-right asymmetry. Semin Cell Dev Biol. 32,80-4頁 |
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13. |
2013 |
論文 |
Asymmetric distribution of dynamic calcium signals in the node of mouse embryo during left-right axis formation. Dev Biol. 376(1),pp.23-30 |
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14. |
2013 |
論文 |
Cluap1 localizes preferentially to the base and tip of cilia and is required for ciliogenesis in the mouse embryo. Dev Biol. 381(1),pp.203-12 |
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15. |
2013 |
論文 |
Pleiotropic and isoform-specific functions for Pitx2 in superior colliculus and hypothalamic neuronal development. Mol Cell Neurosci. 52,pp.128-39 |
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16. |
2012 |
論文 |
Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2. Science 338(6104),pp.226-31 |
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17. |
2012 |
論文 |
EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins. Dev Biol. 371(2),pp.136-45 |
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18. |
2012 |
論文 |
Two rotating cilia in the node cavity are sufficient to break left-right symmetry in the mouse embryo. Nat Commun. 3,pp.622 |
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19. |
2011 |
論文 |
Characterization of Pitx2c expression in the mouse heart using a reporter transgene. Dev Dyn. 240(1),pp.195-203 |
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20. |
2011 |
論文 |
Left-right asymmetry in the level of active Nodal protein produced in the node is translate into left-right asymmetry in the lateral plate of mouse embryos. Dev Biol. 353(2),pp.321-30 |
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21. |
2011 |
論文 |
SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling. Development. 138(10),pp.1913-23 |
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22. |
2010 |
論文 |
Dysregulation of the PDGFRA gene causes inflow tract anomalies including TAPVR: integrating evidence from human genetics and model organisms. Hum Mol Genet. 19(7),pp.1286-301 |
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23. |
2009 |
論文 |
A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome. Nature 460(7252),pp.287-91 |
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24. |
2007 |
論文 |
An Nkx2-5/Bmp2/Smad1 negative feedback lo op controls heart progenitor specification and proliferation. Cell 128(5),pp.947-59 |
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25. |
2007 |
論文 |
Haemodynamics determined by the genetic programme govern asymmetric development of the aortic arch. Nature 450(7167),pp.285-8 |
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26. |
2006 |
論文 |
Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs. Development. 133(15),pp.3015-25 |
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27. |
2006 |
論文 |
The left-right axis in the mouse: from origin to morphology. Development. 133(11),pp.2095-104 |
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28. |
2006 |
論文 |
The mouse embryo autonomously acquires anterior-posterior polarity at implantation. Dev Cell. 10(4),pp.451-9 |
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29. |
2003 |
論文 |
Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis. Development. 130(24),pp.5953-64 |
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30. |
2002 |
論文 |
Determination of left-right patterning of the mouse embryo by artificial nodal flow. Nature. 418(6893),pp.96-9 |
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31. |
2001 |
論文 |
Role of asymmetric signals in left-right patterning in the mouse. Am J Med Genet. 101(4),pp.324-7 |
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32. |
2001 |
論文 |
The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo. Genes Dev. 15(2),pp.213-215 |
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33. |
2001 |
論文 |
The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse. Genes Dev. 15(10),pp.1242-56 |
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34. |
2001 |
論文 |
Two-step regulation of asymmetric Pitx2 expression: intiation by Nodal signaling and maintenance by Nkx2. Molecular Cell 7(1),pp.137-149 |
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35. |
2001 |
論文 |
Two-step regulation of left-right asymmetric expression of Pitx2 : initiation by Nodal signaling and maintenance by Nkx2 Molecular Cell 7(1),pp.137-149 |
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5件表示
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全件表示(35件)
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| 経歴 |
■ 学歴
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■ 所属学会
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| その他 |
■ 研究課題・受託研究・科研費
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■ 現在の専門分野
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■ 科研費研究者番号
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