| 研究概要 |
■ 研究概要
◆研究課題
鳥インフルエンザウイルスの哺乳類での増殖性に関与する内部タンパク質変異の解析
◆研究概要
インフルエンザA型ウイルスは、多様な宿主に感染するが、宿主特異性が存在する。本研究では鳥インフルエンザウイルスの哺乳類での感染性に関わるウイルス内部タンパク質の変異を探索し、パンデミックウイルスの出現を予測することを目的とする。
（１） 野生水禽類から分離されたウイルス内部遺伝子型の異なるH9N2亜型鳥インフルエンザウイルスをマウス継代により増殖性が高まったウイルス株を用いて、各種細胞での増殖性の比較、RNAポリメラーゼタンパク質のクローニングによる、RNAポリメラーゼ活性の比較を行い、増殖性に関与するウイルス内部タンパク質の変異部位の同定を行う。
（２） NPタンパク質と、相互作用する宿主タンパク質の宿主間、および由来する宿主が異なるウイルス株の間での関連性を比較解析する。 |
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| 業績 |
■ 著書・論文歴
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1. |
2016 |
論文 |
Accumulation of a soluble form of human nectin-2 is required for exerting the resistance against herpes simplex virus type 2 infection in transfected cells Acta Virologica 60(1),pp.41-48 |
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2. |
2016 |
論文 |
Cross-protective potential of anti-nucleoprotein human monoclonal antibodies against lethal influenza A virus infection Journal of General Virology |
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3. |
2015 |
論文 |
Systemic L-Kynurenine sulfate administration disrupts object recognition memory, alters open field behavior and decreases c-Fos immunopositivity in C57BI/6 mice Frontiers in Behavioral Neuroscience 9(157) |
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4. |
2014 |
論文 |
Acetyl-l-carnitine normalizes the impaired long-term potentiation and spine density in a rat model of global ischemia Neuroscience 269(6),pp.265-272 |
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5. |
2013 |
論文 |
Antibody survey on avian influenza viruses using egg yolks of ducks in Hanoi between 2010 and 2012 Veterinary Microbiology 166(1-2),pp.179–183 |
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6. |
2013 |
論文 |
Resistance to influenza A virus infection in transformed cell lines expressing an anti-PB2 monoclonal antibody The Veterinary Journal 198(2),pp.487–493 |
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7. |
2013 |
論文 |
The characterization of low pathogenic avian influenza viruses isolated from wild birds in northern Vietnam from 2006 to 2009 Comparative Immunology, Microbiology and Infectiou 36(6),pp.581-590 |
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8. |
2012 |
論文 |
Isolation and characterization of H6N1 and H9N2 avian influenza viruses from Ducks in Hanoi, Vietnam Virus Research 163(2),pp.448-453 |
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9. |
2012 |
論文 |
Molecular epidemiology of avian influenza viruses circulating among healthy poultry flocks in farms in northern Vietnam Preventive Veterinary Medicine 103(2-3),pp.192-200 |
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10. |
2010 |
論文 |
Characterization of H5N1 highly pathogenic avian influenza virus strains isolated from migratory waterfowl in Mongolia on the way back from the southern Asia to their northern territory Virology 406(1),pp.88-94 |
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11. |
2010 |
論文 |
Development of a new disinfectant with very strong anti-influenza viral activity: A preliminary report Environmental Health and Preventive Medicine 15(2),pp.121-123 |
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12. |
2010 |
論文 |
Development of reverse transcription-loop-mediated isothermal amplification (RT-LAMP) assay for detection of avian influenza viruses in field specimens Journal of Veterinary Medical Science 72(4),pp.519-523 |
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13. |
2010 |
論文 |
Possible circulation of H5N1 avian influenza viruses in healthy ducks on farms in northern Vietnam Microbiology and Immunology 54(1),pp.58-62 |
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14. |
2010 |
論文 |
Susceptibility of two species of wild terrestrial birds to infection with a highly pathogenic avian influenza virus of H5N1 subtype Avian Pathology 39(2),pp.95-98 |
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15. |
2008 |
論文 |
A vaccine prepared from a non-pathogenic H7N7 virus isolated from natural reservoir conferred protective immunity against the challenge with lethal dose of highly pathogenic avian influenza virus in chickens Vaccine 26(17),pp.2127-2134 |
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16. |
2006 |
論文 |
Contribution of interferon-β to the immune activation induced by double-stranded DNA Immunology 118(3),302-310頁 |
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17. |
2004 |
論文 |
Treatment of solid sarcomas in immunocompetent mice with novel, oncolytic herpes simplex viruses Otolaryngology - Head and Neck Surgery 130(4),pp.470-478 |
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18. |
2003 |
論文 |
Effective treatment of disseminated peritoneal colon cancer with new replication-competent herpes simplex viruses Hepato-Gastroenterology 50(52),pp.961-966 |
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19. |
2003 |
論文 |
Oncolytic viral therapy using a spontaneously generated herpes simplex virus type 1 variant for disseminated peritoneal tumor in immunocompetent mice Archives of Virology 148(8),pp.813-825 |
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20. |
2002 |
論文 |
Excretion of herpes simplex virus type 2 glycoprotein D into the culture medium Journal of General Virology 83(11),pp.2791–2795 |
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21. |
2002 |
論文 |
Herpes simplex virus type 2 US3 blocks apoptosis induced by sorbitol treatment Microbes and Infection 4(7),pp.707–712 |
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22. |
2002 |
論文 |
Identification and Characterization of the UL56 Gene Product of Herpes Simplex Virus Type 2 Journal of Virology 76(13),pp.6718–6728 |
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23. |
2002 |
論文 |
Identification and Characterization of the UL7 Gene Product of Herpes Simplex Virus Type 2 Virus Genes 24(3),pp.257-266 |
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24. |
2002 |
論文 |
Phosphorylation of cytokeratin 17 by herpes simplex virus type 2 US3 protein kinase Microbiology and Immunology 46/10,707-719 |
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25. |
2002 |
論文 |
Successful Protection by Amantadine Hydrochloride against Lethal Encephalitis Caused by a Highly Neurovirulent Recombinant Influenza A Virus in Mice Virology 303(2),pp.287–296 |
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26. |
2001 |
論文 |
A single amino acid substitution in the ICP27 protein of herpes simplex virus type 1 is responsible for its resistance to leptomycin B. Journal of Virology 75(2),pp.1039–1043 |
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27. |
2001 |
論文 |
Herpes simplex virus encodes a virion-associated protein which promotes long cellular processes in over- expressing cells Genes to Cells 6(11),pp.955-966 |
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28. |
2001 |
論文 |
Identification and characterization of the UL24 gene product of herpes simplex virus type 2. Virus Genes 22(3),pp.321–327 |
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29. |
2001 |
論文 |
The UL14 protein of herpes simplex virus type 2 translocates the minor capsid protein VP26 and the DNA cleavage and packaging UL33 protein into the nucleus of coexpressing cells. Journal of General Virology 82(2),pp.321–330 |
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30. |
2001 |
論文 |
The US11 Gene Product of Herpes Simplex Virus Has Intercellular Trafficking Activity Biochemical and Biophysical Research Communication 288(3),pp.597–602 |
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31. |
2001 |
論文 |
The US2 gene product of herpes simplex virus type 2 interacts with cytokeratin 18 Archives of Virology 146(11),pp.2201–2209 |
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32. |
2000 |
論文 |
Expression of herpes simplex virus type 2 US3 affects the Cdc42/Rac pathway and attenuates c-Jun N-terminal kinase activation Genes to Cells 5(12),pp.1017-1027 |
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33. |
2000 |
論文 |
Herpes simplex virus UL17 protein is associated with B capsids and colocalizes with ICP35 and VP5 in infected cells. Archives of Virology 145(2),pp.417–426 |
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34. |
2000 |
論文 |
Identification of Nuclear Export Signal in UL37 Protein of Herpes Simplex Virus Type 2 Biochemical and Biophysical Research Communication 276(3),pp.1248–1254 |
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35. |
2000 |
論文 |
Mitochondrial distribution and function in herpes simplex virus-infected cells Journal of General Virology 81(2),pp.401-406 |
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36. |
2000 |
論文 |
Precursor genes of future pandemic influenza viruses are perpetuated in ducks nesting in Siberia. Archives of Virology 145(5),pp.885–893 |
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37. |
2000 |
論文 |
The UL34 gene product of herpes simplex virus type 2 is a tail-anchored type II membrane protein that is significant for virus envelopment Journal of General Virology 81(10),pp.2397–2405 |
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38. |
1999 |
論文 |
Identification and characterization of the UL14 gene product of herpes simplex virus type 2 Journal of General Virology 80(9),pp.2423-2431 |
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39. |
1999 |
論文 |
Replacement of Internal Protein Genes, with the Exception of the Matrix, in Equine 1 Viruses by Equine 2 Influenza Virus Genes during Evolution in Nature Journal of Veterinary Medical Science 61(8),pp.987–989 |
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40. |
1998 |
論文 |
An attenuation mechanism of Newcastle disease vaccine strain TCND Archives of Virology 143(6),pp.1129-1143 |
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41. |
1998 |
論文 |
Potentially virulent Newcastle disease viruses are maintained in migratory waterfowl populations. Japanese Journal of Veterinary Research 45(4),pp.207-215 |
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42. |
1994 |
論文 |
Acquisition of pathogenicity of a Newcastle disease virus isolated from a Japanese quail by intracerebral passage in chickens Japanese Journal of Veterinary Research 42(3-4),pp.147-156 |
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5件表示
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全件表示(42件)
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| 経歴 |
■ 学歴
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■ 所属学会
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| その他 |
■ 研究課題・受託研究・科研費
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■ 現在の専門分野
| 生態学、環境学, 獣医学, ウイルス学, その他 （キーワード：インフルエンザウイルス）
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■ 取得特許
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