教員情報 - 白鳥　秀卓

1.	2020/12	論文	CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components （共著）
2.	2020/11	論文	CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module Nature Communications （共著）
3.	2020/07	論文	Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2 Neuron （共著）
4.	2020/07	論文	Role of Ca 2+ transients at the node of the mouse embryo in breaking of left-right symmetry Science Advances （共著）
5.	2018/08	論文	Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters. Elife. 7,pp.pii: e36435 （共著）
6.	2017/03	論文	A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking. Dev Cell. 40(5),pp.439-452 （共著）
7.	2016/08	論文	TTC25 Deficiency Results in Defects of the Outer Dynein Arm Docking Machinery and Primary Ciliary Dyskinesia with Left-Right Body Asymmetry Randomization. Am J Hum Genet. 99(2),pp.460-469 （共著）
8.	2015/10	論文	Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo. PLoS One. 10(10),pp.e0140831 （共著）
9.	2014	論文	Pih1d3 is required for cytoplasmiccytoplasmic pre-assembly of axonemal dyneins in mouse sperm. J Cell Biol. 204(2),pp.203-13
10.	2014	論文	Self-regulated left-right asymmetric expression of Pitx2c in the developing mouse limb. Dev Biol. 395(2),pp.331-41
11.	2014	論文	TGFβ signaling in establishing left-right asymmetry. Semin Cell Dev Biol. 32,80-4頁
12.	2013	論文	Asymmetric distribution of dynamic calcium signals in the node of mouse embryo during left-right axis formation. Dev Biol. 376(1),pp.23-30
13.	2013	論文	Cluap1 localizes preferentially to the base and tip of cilia and is required for ciliogenesis in the mouse embryo. Dev Biol. 381(1),pp.203-12
14.	2013	論文	Pleiotropic and isoform-specific functions for Pitx2 in superior colliculus and hypothalamic neuronal development. Mol Cell Neurosci. 52,pp.128-39
15.	2012	論文	Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2. Science 338(6104),pp.226-31
16.	2012	論文	EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins. Dev Biol. 371(2),pp.136-45
17.	2012	論文	Two rotating cilia in the node cavity are sufficient to break left-right symmetry in the mouse embryo. Nat Commun. 3,pp.622
18.	2011	論文	Characterization of Pitx2c expression in the mouse heart using a reporter transgene. Dev Dyn. 240(1),pp.195-203
19.	2011	論文	Left-right asymmetry in the level of active Nodal protein produced in the node is translate into left-right asymmetry in the lateral plate of mouse embryos. Dev Biol. 353(2),pp.321-30
20.	2011	論文	SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling. Development. 138(10),pp.1913-23
21.	2010	論文	Dysregulation of the PDGFRA gene causes inflow tract anomalies including TAPVR: integrating evidence from human genetics and model organisms. Hum Mol Genet. 19(7),pp.1286-301
22.	2009	論文	A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome. Nature 460(7252),pp.287-91
23.	2007	論文	An Nkx2-5/Bmp2/Smad1 negative feedback lo op controls heart progenitor specification and proliferation. Cell 128(5),pp.947-59
24.	2007	論文	Haemodynamics determined by the genetic programme govern asymmetric development of the aortic arch. Nature 450(7167),pp.285-8
25.	2006	論文	Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs. Development. 133(15),pp.3015-25
26.	2006	論文	The left-right axis in the mouse: from origin to morphology. Development. 133(11),pp.2095-104
27.	2006	論文	The mouse embryo autonomously acquires anterior-posterior polarity at implantation. Dev Cell. 10(4),pp.451-9
28.	2003	論文	Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis. Development. 130(24),pp.5953-64
29.	2002	論文	Determination of left-right patterning of the mouse embryo by artificial nodal flow. Nature. 418(6893),pp.96-9
30.	2001	論文	Role of asymmetric signals in left-right patterning in the mouse. Am J Med Genet. 101(4),pp.324-7
31.	2001	論文	The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo. Genes Dev. 15(2),pp.213-215
32.	2001	論文	The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse. Genes Dev. 15(10),pp.1242-56
33.	2001	論文	Two-step regulation of asymmetric Pitx2 expression: intiation by Nodal signaling and maintenance by Nkx2. Molecular Cell 7(1),pp.137-149
34.	2001	論文	Two-step regulation of left-right asymmetric expression of Pitx2 : initiation by Nodal signaling and maintenance by Nkx2 Molecular Cell 7(1),pp.137-149
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全件表示(34件)

経歴

■ 学歴

(学位取得)

大阪大学医学

■ 所属学会

1.		日本分子生物学会
2.		日本獣医学会

その他

■ 研究課題・受託研究・科研費

1.		Function and transcriptional regulation of the transcription factor Pitx2 involved in left-right-specific morphogenesis
2.		左右非対称な形態形成に関与する転写因子Pitx2の機能と転写調節機構の解明
3.	2020/04～2023/03	左右非対称な内臓器官の形態変化のしくみとその役割基盤研究(C)

■ 現在の専門分野

発生生物学

科研

■ 科研費研究者番号

90362590

■ 研究概要

◆研究課題哺乳動物の胚発生と老化機構の解析 ◆研究概要胚発生における左右軸形成機構、アミノ酸代謝が支配する胚発生や老化機構には、まだまだ不明なことが多い。本研究では、腎臓や肝臓など左右非対称に形成される器官の形成機構を解析する。さらに、形態的に左右非対称に形成される肝臓において、機能的な左右差もあるのかどうか解析する。また、胚発生や老化に関与するアミノ酸代謝経路の役割を明らかにする。　具体的には、以下の内容について研究を進める。・腎臓や肝臓が左右非対称に形成されるしくみ・生殖器と胚発生における細胞外マトリックス因子の役割・肝臓の機能的な左右差の解析・毛包の形成と維持におけるアミノ酸合成酵素の役割・血糖調節におけるアミノ酸合成酵素の役割・胚発生におけるアミノ酸代謝酵素の役割