セオ ミスズ   SEO MISUZU
  瀬尾 美鈴
   所属   京都産業大学  生命科学部 先端生命科学科
   職種   教授
発表年月日 2019/08/05
発表テーマ Anosmin-1 activates vascular endothelial growth factor receptor and its related signaling pathway for olfactory bulb angiogenesis
会議名 Gordon Research Conference -Angiogenesis
主催者 Gordon Research Conference
学会区分 国際学会
発表形式 ポスター
単独共同区分 共同
国名 アメリカ合衆国
開催地名 Newport
開催期間 2019/08/04~2019/08/09
発表者・共同発表者 Shoko Matsushima, Akio Shimizu, Manami Kondo, Hirotsugu Asano, Nobuhiro Ueno, Hironao Nakayama, Naoko Sato, Hisakazu Ogita and Misuzu Kurokawa-Seo
概要 Anosmin-1 is a secreted glycoprotein encoded by the ANOS1 gene, and the loss of function causes Kallmann syndrome (KS), which is characterized by anosmia and hypogonadism due to olfactory bulb (OB) dysfunction. In KS, disordered angiogenesis is observed in OB, resulting in its hypoplasia. Anosmin-1 was detected on the vessel-like structure in OB of chick embryos, and promoted the outgrowth of vascular sprouts in the OB tissue culture assay. We newly identified that anosmin-1 activated VEGF receptor-2 (VEGFR2) by directly binding to it, and its downstream signaling molecules, phospholipase Cgamma1 (PLCgamma1) and protein kinase C (PKC). These results suggest that anosmin-1 plays a key role in the angiogenesis of developing OB through the VEGFR2–PLCgamma1–PKC axis by enhancing the VEGF function.