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セオ ミスズ
SEO MISUZU
瀬尾 美鈴 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 発表年月日 | 2020/09/15 |
| 発表テーマ | Inhibition of VEGF-A/NRP1 signaling pathway that promotes cancer cells progression by RNA interference. |
| 会議名 | 第93回日本生化学会大会 |
| 主催者 | 日本生化学会 |
| 学会区分 | 全国学会 |
| 発表形式 | ポスター |
| 単独共同区分 | 共同 |
| 開催地名 | 横浜 |
| 開催期間 | 2020/09/14～2020/09/16 |
| 発表者・共同発表者 | Md.M. Hasan, S. Nakanishi, A. Yamaguchi, M. Wake, N. Ueno, M. Kurokawa-Seo |
| 概要 | Neuropilin-1 (NRP1) is a 130 kDa transmembrane protein crucial for mediating the effects of Vascular endothelial growth factor-A (VEGF-A) on tumor cells promoting tumorigenesis. VEGF-A binding to NRP-1 induced the interaction between GIPC1 and Syx. PC3M (prostate cancer) and U87MG (brain tumor) cells secreted VEGF-A activated RhoA via NRP1 to upregulate the tumorigenic activity in an autocrine manner and supported the VEGF-A/NRP1 signaling pathway in cancer cells. GIPC1 formed complex with Syx that led to the activation of RhoA. NRP1/GIPC1 or GIPC1/Syx interaction occurs in VEGF-A/NRP1 signaling pathway. The RNA interference of GIPC1 or Syx reduced active RhoA. Knockdown of endogenous VEGF-A/NRP1 or GIPC/Syx expression inhibit VEGF-A/NRP1 signaling pathway in vitro. Autocrine VEGF-A signaling is crucial for cancer initiation and NRP1 is necessary for this VEGF-A/NRP1 signaling. Targeting VEGF-A/NRP1 signaling provides to develop new cancer therapeutic drugs. |