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カトウ ケイコ
KATO KEIKO
加藤 啓子 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 期間 | 1998/02 |
| 名称 | Blockade of neuropsin, a serine protease, ameliorates kindling epilepsy |
| 区分 | その他 |
| 開催場所 | BLACKWELL SCIENCE LTD EUROPEAN JOURNAL OF NEUROSCIENCE |
| 発表者・共同発表者等 | Y Momota,S Yoshida,J Ito,M Shibata,K Kato,K Sakurai,K Matsumoto,S Shiosaka |
| 発表・展示等 | The behavioural and electrographical abnormalities associated with seizures in epileptic (kindled) mice correspond with those of human epilepsy. In kindled mice, neuropsin was markedly increased in the hippocampus and cerebral cortices. A single intraventricular injection of monoclonal antibodies specific to neuropsin reduced or eliminated the epileptic pattern noted on electroencephalograms and, as a result markedly inhibited the progression of kindling. Therefore, neuropsin appears to be a key protein controlling pathogenic events in the hippocampus, and thus neuropsin inhibitors might be useful for treatment of epilepsy. |
| DOI | 10.1046/j.1460-9568.1998.00068.x |