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カトウ ケイコ
KATO KEIKO
加藤 啓子 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 期間 | 2002 |
| 名称 | Extracellular serine protease neuropsin (KLK8) modulates neurite outgrowth and fasciculation of mouse hippocampal neurons in culture |
| 区分 | その他 |
| 開催場所 | Neurosci. Lett |
| 発表者・共同発表者等 | T Oka,M Akisada,A Okabe,K Sakurai,S Shiosaka,K Kato |
| 発表・展示等 | A serine protease neuropsin expressed in the hippocampus of adult brain has been implicated in synaptic plasticity. We report here that endogenous neuropsin was localized extracellularly in neuronal cell bodies and their neurites in mouse hippocampal cultures. Furthermore, we found that, in cultured mouse hippocampal neurons, recombinant neuropsin enhanced neurite projection from soma after 14 h of culture and neuronal aggregation with neurite fascicles at 48 h. This suggests that neuropsin is involved in neurite outgrowth and fasciculation during the development of the nervous system. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. |
| DOI | 10.1016/S0304-3940(01)02470-3 |