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カトウ ケイコ
KATO KEIKO
加藤 啓子 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 期間 | 2009/06 |
| 名称 | Spontaneous Endometrial Hyperplasia in the Uteri of IL-2 Receptor Beta-Chain Transgenic Mice |
| 区分 | その他 |
| 開催場所 | SOCIETY REPRODUCTION & DEVELOPMENT-SRD JOURNAL OF REPRODUCTION AND DEVELOPMENT |
| 発表者・共同発表者等 | Ken Kusakabe,Yasuo Kiso,Eiichi Hondo,Ai Takeshita,Keiko Kato,Toshiya Okada,Masa-Aki Shibata,Yoshinori Otsuki |
| 発表・展示等 | We found frequent and spontaneous proliferation of glandular epithelium and dilated cysts in the uteri of interleukin-2 receptor (IL2R) beta-chain transgenic (Tg2R beta) mice. The aim of this study was to examine the involvement of IL2R beta-chain in the pathogenesis of endometrial hyperplasia (EH). Mouse uteri and serum were collected from Tg2R beta and normal littermates (NL), which were classified into three groups according to age. The incidence of EH increased in an age-dependent manner in both types of mice. However, in old age, Tg2R beta mice showed more serious phenotypes of EH than NL. Immunohistochemical analysis revealed specific localization of IL2R beta-chain in the glandular epithelial cells, with a correlation to the degree of EH, not only in the Tg2R beta uteri but also in the NL uteri. Immunoreactions of CD3 and CD25 were detected in the uteri of Tg2R beta but were weak in the uteri of NL, and CD25-positive cells were distributed in the endometrial stroma and myometrium in the Tg2R beta mice. These findings suggest that the IL2R beta-chain induces growth potential for glandular epithelial cells and an immune-privileged condition mediated by CD25+regulatory-T cells. |
| DOI | 10.1262/jrd.20171 |