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カトウ ケイコ
KATO KEIKO
加藤 啓子 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 期間 | 2008/08 |
| 名称 | Increase of GQ1b in the hippocampus of mice following kindled-seizures |
| 区分 | その他 |
| 開催場所 | ELSEVIER IRELAND LTD NEUROSCIENCE LETTERS |
| 発表者・共同発表者等 | Keiko Kato,Masao Iwamori,Yoshio Hirabayashi |
| 発表・展示等 | The ganglioside GQ1b facilitates the influx of Ca(2+) in brain synaptosomes and enhances ATP-induced long-term potentiation in hippocampal slices. Anti-GQ1b antibody impairs the function of peripheral neurons, for example, it had pathogenic effects on presynaptic neuronal membranes and perisynaptic Schwann cells in a mouse model of Guillain-Barre syndrome. The present study demonstrated in vivo that the level of endogenous GQ1b was relevant to neural function in the brain, in that it increased following seizures in amygdaloid kindling mice. GQ1b is subject to epileptogenic regulation and may play a role in the development of epilepsy. (c) 2008 Elsevier Ireland Ltd. All rights reserved. |
| DOI | 10.1016/j.neulet.2008.06.058 |