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エンドウ トシヤ
ENDO TOSHIYA
遠藤 斗志也 所属 京都産業大学 生命科学部 先端生命科学科 職種 客員教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2010/11 |
| 形態種別 | その他 |
| 査読 | 査読あり |
| 標題 | Structural Basis for the Disulfide Relay System in the Mitochondrial Intermembrane Space |
| 執筆形態 | その他 |
| 掲載誌名 | ANTIOXIDANTS & REDOX SIGNALING |
| 出版社・発行元 | MARY ANN LIEBERT, INC |
| 巻・号・頁 | 13(9),pp.1359-1373 |
| 著者・共著者 | Toshiya Endo,Koji Yamano,Shin Kawano |
| 概要 | Mitochondria contain two biological membranes. Although reducing agents can diffuse from the cytosol into the intermembrane space (IMS) between the outer and inner mitochondrial membranes, the IMS has a dedicated disulfide relay system to introduce disulfide bonds into mainly small and soluble proteins. This system consists of two essential proteins, a disulfide carrier Tim40/Mia40 and a flavin-dependent sulfhydryl oxidase Erv1, high-resolution structures that have recently become available. Tim40/Mia40 transfers disulfide bonds to newly imported IMS proteins by dithiol/disulfide exchange reactions involving mixed disulfide intermediates. Tight folding by introduction of disulfide bonds prevents egress of these small IMS proteins, resulting in their selective retention in the compartment. After disulfide transfer from Tim40/Mia40 to substrate proteins, Tim40/Mia40 is reoxidized again by Erv1, which is then oxidized by electron transfer to either cytochrome c or molecular oxygen. Here we review the recent advancement of the knowledge on the mechanism of the disulfide relay system in the mitochondrial IMS, especially shedding light on the structural aspects of its components. Antioxid. Redox Signal. 13, 1359-1373. |
| DOI | 10.1089/ars.2010.3099 |
| ISSN | 1523-0864/1557-7716 |