|
エンドウ トシヤ
ENDO TOSHIYA
遠藤 斗志也 所属 京都産業大学 生命科学部 先端生命科学科 職種 客員教授 |
|
| 言語種別 | 英語 |
| 発行・発表の年月 | 2011/03 |
| 形態種別 | その他 |
| 査読 | 査読あり |
| 標題 | Structural insight into the mitochondrial protein import system |
| 執筆形態 | その他 |
| 掲載誌名 | BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES |
| 出版社・発行元 | ELSEVIER SCIENCE BV |
| 巻・号・頁 | 1808(3),pp.955-970 |
| 著者・共著者 | Toshiya Endo,Koji Yamano,Shin Kawano |
| 概要 | Mitochondrial functions rely on precise and efficient transport of 1000-1500 different mitochondrial proteins from the cytosol to appropriate mitochondria! subcompartments. Those mitochondrial protein transport processes are mediated by the dedicated mitochondrial protein import system comprised of translocators in the outer and inner mitochondrial membranes and soluble factors in the cytosol, intermembrane space, and matrix. In the last decade, high-resolution structures of many of the components of the mitochondrial protein import machineries have become available, which has significantly advanced our understanding of the molecular mechanisms of mitochondrial protein transport. Here we review the currently available high-resolution structures of the components of the mitochondrial protein import machineries that afford structural and mechanistic insight into how the mitochondrial import system works. This article is part of a Special Issue entitled Protein translocation across or insertion into membranes. (C) 2010 Elsevier B.V. All rights reserved. |
| DOI | 10.1016/j.bbamem.2010.07.018 |
| ISSN | 0005-2736 |