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エンドウ トシヤ
ENDO TOSHIYA
遠藤 斗志也 所属 京都産業大学 生命科学部 先端生命科学科 職種 客員教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2014/03 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | NMR analyses on the interactions of the yeast Tim50 C-terminal region with the presequence and Tim50 core domain |
| 執筆形態 | その他 |
| 掲載誌名 | FEBS LETTERS |
| 出版社・発行元 | ELSEVIER SCIENCE BV |
| 巻・号・頁 | 588(5),pp.678-684 |
| 著者・共著者 | Bytul Rahman,Shin Kawano,Kaori Yunoki-Esaki,Takahiro Anzai,Toshiya Endo |
| 概要 | The mitochondrial targeting signal in the presequence of mitochondrial precursor proteins is recognized by Tom20 and subsequently by Tim50 in mitochondria. Yeast Tim50 contains two presequence binding sites in the conserved core domain and in the fungi-specific C-terminal presequence binding domain (PBD). We report the NMR analyses on interactions of a shorter variant of PBD (sPBD), a shorter variant of PBD, with presequences. The presequence is recognized by sPBD in a similar manner to Tom20. sPBD can also bind to the core domain of Tim50 through the presequence binding region, which could promote transfer of the presequence from sPBD to the core domain in Tim50. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
| DOI | 10.1016/j.febslet.2013.12.037 |
| ISSN | 0014-5793/1873-3468 |