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エンドウ トシヤ
ENDO TOSHIYA
遠藤 斗志也 所属 京都産業大学 生命科学部 先端生命科学科 職種 客員教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2014/06 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | A novel import route for an N-anchor mitochondrial outer membrane protein aided by the TIM23 complex |
| 執筆形態 | その他 |
| 掲載誌名 | EMBO REPORTS |
| 出版社・発行元 | WILEY-BLACKWELL |
| 巻・号・頁 | 15(6),pp.670-677 |
| 著者・共著者 | Jiyao Song,Yasushi Tamura,Tohru Yoshihisa,Toshiya Endo |
| 概要 | The membrane topology of Om45 in the yeast mitochondrial outer membrane ( OM) is under debate. Here, we confirm that Om45 is anchored to the OM from the intermembrane space (IMS) by its N-terminal hydrophobic segment. We show that import of Om45 requires the presequence receptors, Tom20 and Tom22, and the import channel of Tom40. Unlike any of the known OM proteins, Om45 import requires the TIM23 complex in the inner membrane, a translocator for presequence-containing proteins, and the membrane potential (Delta Psi). Therefore, Om45 is anchored to the OM via the IMS by a novel import pathway involving the TIM23 complex. |
| DOI | 10.1002/embr.201338142 |
| ISSN | 1469-221X/1469-3178 |