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エンドウ トシヤ
ENDO TOSHIYA
遠藤 斗志也 所属 京都産業大学 生命科学部 先端生命科学科 職種 客員教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2016/09 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Identification of multi-copy suppressors for endoplasmic reticulum-mitochondria tethering proteins in Saccharomyces cerevisiae |
| 執筆形態 | その他 |
| 掲載誌名 | FEBS LETTERS |
| 出版社・発行元 | WILEY-BLACKWELL |
| 巻・号・頁 | 590(18),pp.3061-3070 |
| 著者・共著者 | Rieko Kojima,Shu Kajiura,Hiromi Sesaki,Toshiya Endo,Yasushi Tamura |
| 概要 | In yeast, the endoplasmic reticulum (ER)-mitochondria encounter structure (ERMES) tethers the ER to mitochondria, but its primary function remains unclear. To gain insight into ERMES functions, we screened multi-copy suppressors of the growth-defective phenotype of mmm1 cells, which lack a core component of ERMES, and identified MCP1, MGA2, SPT23, and YGR250C (termed RIE1). Spt23 and Mga2 are homologous transcription factors known to activate transcription of the OLE1 gene, which encodes the fatty acid 9 desaturase. We found that Ole1 partially relieves the growth defects of ERMES-lacking cells, thus uncovering a relationship between fatty acid metabolism and ERMES functions. |
| DOI | 10.1002/1873-3468.12358 |
| ISSN | 0014-5793/1873-3468 |
| PMID | 27531107 |