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エンドウ トシヤ
ENDO TOSHIYA
遠藤 斗志也 所属 京都産業大学 生命科学部 先端生命科学科 職種 客員教授 |
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| 発行・発表の年月 | 2002/09/02 |
| 形態種別 | その他 |
| 標題 | Functions of outer membrane receptors in mitochondrial protein import |
| 執筆形態 | その他 |
| 掲載誌名 | Biochim Biopys Acta |
| 巻・号・頁 | 1592, 3-14,3-14頁 |
| 著者・共著者 | Toshiya Endo,Daisuke Kohda |
| 概要 | Most mitochondrial proteins are synthesized in the cytosol as precursor proteins and are imported into mitochondria. The targeting signals for mitochondria are encoded in the presequences or in the mature parts of the precursor proteins, and are decoded by the receptor sites in the translocator complex in the mitochondrial outer membrane. The recently determined NMR structure of the general import receptor Tom20 in a complex with a presequence peptide reveals that, although the amphiphilicity and positive charges of the presequence is essential for the import ability of the presequence, Tom20 recognizes only the amphiphilicity, but not the positive charges. This leads to a new model that different features associated with the mitochondrial targeting sequence of the precursor protein can be recognized by the mitochondrial protein import system in different steps during the import. © 2002 Elsevier Science B.V. All rights reserved. |
| DOI | 10.1016/S0167-4889(02)00259-8 |
| ISSN | 0167-4889 |
| PMID | 12191763 |
| PermalinkURL | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0037009087&origin=inward |