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エンドウ トシヤ
ENDO TOSHIYA
遠藤 斗志也 所属 京都産業大学 生命科学部 先端生命科学科 職種 客員教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2017 |
| 形態種別 | 論文集（書籍）内論文 |
| 査読 | 査読あり |
| 標題 | Role of intra- and inter-mitochondrial membrane contact sites in yeast phospholipid biogenesis |
| 執筆形態 | その他 |
| 掲載誌名 | Advances in Experimental Medicine and Biology |
| 出版社・発行元 | Springer New York LLC |
| 巻・号・頁 | 997,pp.121-133 |
| 著者・共著者 | Yasushi Tamura,Toshiya Endo |
| 概要 | Eukaryotic cells exhibit intracellular compartments called organelles wherein various specialized enzymatic reactions occur. Despite the specificity of the characteristic functions of organelles, recent studies have shown that distinct organelles physically connect and communicate with each other to maintain the integrity of their functions. In yeast, multiple inter- and intramitochondrial membrane contact sites (MCSs) were identified to date and were proposed to be involved in phospholipid biogenesis. In the present article, we focus on inter- and intra-organellar MCSs involving mitochondria and their tethering factors, such as the ERMES (endoplasmic reticulum (ER)–mitochondria encounter structure) complex and EMC (conserved ER membrane protein complex) between mitochondria and the ER, vCLAMP (vacuole and mitochondria patch) between mitochondria and vacuoles, and the MICOS (mitochondrial contact site) complex between the mitochondrial outer and inner membranes (MOM and MIM). All of these membrane-tethering factors were proposed to be involved in phospholipid biogenesis. Furthermore, the existence of functional interconnections among multiple organelle contact sites is suggested. In the present article, we summarize the latest discoveries in regard to MCSs and MCS-forming factors involving mitochondria and discuss their molecular functions, with particular focus on phospholipid metabolism in yeast. |
| DOI | 10.1007/978-981-10-4567-7_9 |
| ISSN | 2214-8019 |
| PMID | 28815526 |