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エンドウ トシヤ
ENDO TOSHIYA
遠藤 斗志也 所属 京都産業大学 生命科学部 先端生命科学科 職種 客員教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2018/01/01 |
| 形態種別 | その他 |
| 査読 | 査読あり |
| 標題 | Inactivation of cardiolipin synthase triggers changes in mitochondrial morphology |
| 執筆形態 | その他 |
| 掲載誌名 | FEBS Letters |
| 出版社・発行元 | Wiley Blackwell |
| 巻・号・頁 | 592(2),pp.209-218 |
| 著者・共著者 | Ayaka Matsumura,Jun Higuchi,Yasunori Watanabe,Masahiro Kato,Keigo Aoki,Shiori Akabane,Toshiya Endo,Toshihiko Oka |
| 概要 | Mitochondrial tubular structures are maintained by a balance between membrane fusion and fission that is regulated by various factors, including Drp1 and mitofusin/fzo-1. Here we report the role of cardiolipin (CL) synthase in the regulation of mitochondrial morphology. Knockdown of CL synthase induced mitochondrial elongation in nematode and human cells. Knockdown of both nematode cardiolipin synthase and drp-1 or fzo-1 suggested that knocking down CL synthase decreases mitochondrial division. Mass spectrometric analysis of human CL synthase-knocked down cells revealed a decreased amount of CL and an accumulation of phosphatidylglycerol, a CL precursor. Knockdown of other genes involved in CL synthesis did not influence mitochondrial morphology. Thus, mitochondrial elongation may result from the accumulation of phosphatidylglycerol rather than decreased CL. |
| DOI | 10.1002/1873-3468.12948 |
| ISSN | 1873-3468 |
| PMID | 29251771 |