|
エンドウ トシヤ
ENDO TOSHIYA
遠藤 斗志也 所属 京都産業大学 生命科学部 先端生命科学科 職種 客員教授 |
|
| 言語種別 | 英語 |
| 発行・発表の年月 | 1995/02 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | MITOCHONDRIAL PRESEQUENCES CAN INDUCE AGGREGATION OF UNFOLDED PROTEINS |
| 執筆形態 | その他 |
| 掲載誌名 | FEBS LETTERS |
| 出版社・発行元 | ELSEVIER SCIENCE BV |
| 巻・号・頁 | 359(1),pp.93-96 |
| 著者・共著者 | T ENDO,S MITSUI,D ROISE |
| 概要 | We have studied the interactions between various synthetic peptides and two model unfolded proteins, reduced alpha-lactalbumin and reduced and carboxymethylated alpha-lactalbumin. We found that mitochondrial presequences could induce aggregation of the unfolded alpha-lactalbumins but not of the native alpha-lactalbumin. The presequence-induced aggregation of unfolded alpha-lactalbumin was dependent on electrostatic interactions and on the amphiphilicity of the presequences. Since positive charge and amphiphilicity are necessary for the targeting function of mitochondrial presequences, presequence-induced aggregation may be responsible for the instability of mitochondrial precursor proteins and may need to be inhibited by binding factors in the cytosol. |
| ISSN | 0014-5793 |