|
エンドウ トシヤ
ENDO TOSHIYA
遠藤 斗志也 所属 京都産業大学 生命科学部 先端生命科学科 職種 客員教授 |
|
| 言語種別 | 英語 |
| 発行・発表の年月 | 2005/01 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Identification of a novel member of yeast mitochondrial Hsp70-associated motor and chaperone proteins that facilitates protein translocation across the inner membrane |
| 執筆形態 | その他 |
| 掲載誌名 | FEBS LETTERS |
| 出版社・発行元 | ELSEVIER SCIENCE BV |
| 巻・号・頁 | 579(2),pp.507-511 |
| 著者・共著者 | H Yamamoto,T Momose,Y Yatsukawa,C Ohshima,D Ishikawa,T Sato,Y Tamura,Y Ohwa,T Endo |
| 概要 | Here, we report the identification of yeast 15-kD Tim15/Zim17, a new member of mitochondrial Hsp70 (mtHsp70)-associated motor and chaperone (MMC) proteins. The 15-kD MMC protein is a peripheral inner membrane protein with a zinc-finger motif. Depletion of the 15-kD protein led to impaired import of presequence-containing proteins into the matrix in vivo and in vitro. Overexpression of the 15-kD protein rescued the functional defects of mtHsp70 in ssc1-3 cells, and a fusion protein containing the 15-kD protein physically interacts with purified mtHsp70. Tim15/Zim17 therefore cooperates with mtHsp70 to facilitate import of presequence-containing proteins into the matrix. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
| DOI | 10.1016/j.febslet.2004.12.018 |
| ISSN | 0014-5793 |