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セオ ミスズ
SEO MISUZU
瀬尾 美鈴 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2020/01 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Anosmin-1 activates vascular endothelial growth factor receptor and its related signaling pathway for olfactory bulb angiogenesis. |
| 執筆形態 | 共著 |
| 掲載誌名 | Sci. Rep. |
| 掲載区分 | 国外 |
| 出版社・発行元 | Springer Nature |
| 巻・号・頁 | 10(1),pp.188 |
| 担当区分 | 責任著者 |
| 著者・共著者 | Matsushima S, Shimizu A, Kondo M, Asano H, Ueno N, Nakayama H, Sato N, Komeno M, Ogita H, Kurokawa-Seo M. |
| 概要 | Anosmin-1 is a secreted glycoprotein encoded by the ANOS1 gene, and its loss of function causes Kallmann syndrome (KS), which is characterized by anosmia and hypogonadism due to olfactory bulb (OB) dysfunction. However, the physiological function of anosmin-1 remains to be elucidated. In this study, we examined the involvement of Anosmin-1 in angiogenic processes and found that Anosmin-1 plays a key role in the angiogenesis of developing OB through the VEGFR2–PLCγ1–PKC axis by enhancing the VEGF function. |
| DOI | 10.1038/s41598-019-57040-3 |
| ISBN | 31932617 |
| PMID | PMC6957483 |