ヨコヤマ ケン   YOKOYAMA KEN
  横山 謙
   所属   京都産業大学  生命科学部 先端生命科学科
   職種   教授
言語種別 日本語
発行・発表の年月 2020/11
形態種別 研究論文
査読 査読あり
標題 Identification of chemical compounds as an inhibitor of mitochondrial ATP synthesis, leading to an increased stress resistance and an extended lifespan in C. elegans
執筆形態 共著
掲載区分国内
担当区分 最終著者
概要 In this study, we present chemical compounds, revealed by systematic screening of chemical libraries, which inhibit mitochondrial ATP synthesis in mammalian cells. Our study demonstrates that these compounds alter the body length and promote the oxidative stress response which leads to an increased longevity in Caenorhabditis elegans. Thus, our study identifies chemical compounds that may have potential therapeutic applications through affecting the mitochondrial function.