ヨコヤマ ケン   YOKOYAMA KEN
  横山 謙
   所属   京都産業大学  生命科学部 先端生命科学科
   職種   教授
言語種別 英語
発行・発表の年月 2018/01
形態種別 研究論文
査読 査読あり
標題 General anesthetics cause mitochondrial dysfunction and reduction of intracellular ATP levels
執筆形態 共著
掲載誌名 PLoS ONE
掲載区分国外
出版社・発行元 Public Library of Science
巻・号・頁 13(1),pp.e0190213
著者・共著者 Jun-ichi Kishikawa, Yuki Inoue, Makoto Fujikawa, Kenji Nishimura, Atsuko Nakanishi, Tsutomu Tanabe, Hiromi Imamura, Ken Yokoyama
概要 General anesthetics are indispensable for effective clinical care. Although, the mechanism of action of general anesthetics remains controversial, lipid bilayers and proteins have been discussed as their targets. In this study, we focused on the relationship between cellular ATP levels and general anesthetics. The ATP levels of nematodes and cultured mammalian cells were decreased by exposure to three general anesthetics: isoflurane, pentobarbital, and 1-phenoxy-2-propanol. Furthermore, these general anesthetics abolished mitochondrial membrane potential, resulting in the inhibition of mitochondrial ATP synthesis. These results suggest that the observed decrease of cellular ATP level is a common phenomenon of general anesthetics.
DOI 10.1371/journal.pone.0190213
ISSN 1932-6203
PMID 29298324