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ツゲ ヒデアキ
TSUGE HIDEAKI
津下 英明 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2008/06 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Structure of an archaeal alanine : glyoxylate aminotransferase |
| 執筆形態 | その他 |
| 掲載誌名 | ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY |
| 出版社・発行元 | WILEY-BLACKWELL |
| 巻・号・頁 | 64(64(6):),pp.696-699 |
| 著者・共著者 | Haruhiko Sakuraba,Kazunari Yoneda,Kiyo Takeuchi,Hideaki Tsuge,Nobuhiko Katunuma,Toshihisa Ohshima |
| 概要 | The crystal structure of a novel alanine: glyoxylate aminotransferase from the hyperthermophilic archaeon Thermococcus litoralis was determined at 2.3 angstrom resolution. The asymmetric unit contains four homologous subunits and the functional tetramer is generated by noncrystallographic 222 symmetry. Although the main-chain coordinates of the monomer of the Thermococcus litoralis enzyme showed a high degree of similarity to those of aspartate aminotransferase from Thermus thermophilus HB8, the amino-acid residues involved in substrate binding in the aspartate aminotransferase are only partially conserved in the Thermococcus litoralis enzyme. This may account for the difference in the substrate specificities of the two enzymes. |
| DOI | 10.1107/S0907444908006732 |
| ISSN | 0907-4449 |