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イタノ ナオキ
ITANO NAOKI
板野 直樹 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2014/06 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | New Visible Endotracheal Intubation Method Using the Endoscope System for Mice Inhalational Anesthesia |
| 執筆形態 | その他 |
| 掲載誌名 | JOURNAL OF VETERINARY MEDICAL SCIENCE |
| 出版社・発行元 | JAPAN SOC VET SCI |
| 巻・号・頁 | 76(6),pp.863-868 |
| 著者・共著者 | Kenjiro Konno,Naoki Itano,Teppei Ogawa,Mika Hatakeyama,Kyoko Shioya,Noriyuki Kasai |
| 概要 | Appropriate and effective anesthesia is critical, because it has a strong influence on laboratory animals, and its affect greatly impacts the experimental data. Inhalational anesthesia by endotracheal intubation is currently prevailing in general anesthesia and is prefered over injection anesthesia, especially for large laboratory animals, because it is a safe and easy control agent. However, it is not common for small laboratory animals, because of the high degree of technical skills required. We assessed the capability of use for mice of the endotracheal intubation by using the endoscope system "TESALA AE-C1" and inhalational anesthesia using a ventilator. Endotracheal intubation was successfully performed on all 10 C57BL/6 mice injected with M/M/B: 0.3/4/5 comprised of medetomidine, midazoram and butorphanol, at a dose of 0.3 mg/kg + 4.0 mg/kg + 5.0 mg/kg body weight/mouse, respectively. After the intubated mice were connected with the inhalational anesthesia circuit and the ventilator, vital signs were measured until 15 mm after the connection. The data with M/M/B: 0.3/4/5 showed stable and normal values, which indicated that this new endotracheal intubation method was simple, reliable and safe, which mean that this anesthesia is favorable in regard to the animal's welfare. |
| DOI | 10.1292/jvms.13-0647 |
| ISSN | 0916-7250/1347-7439 |