イタノ ナオキ   ITANO NAOKI
  板野 直樹
   所属   京都産業大学  生命科学部 先端生命科学科
   職種   教授
言語種別 英語
発行・発表の年月 1997/01
形態種別 研究論文
査読 査読あり
標題 Hyaluronic acid of wound fluid in adult and fetal rabbits
執筆形態 その他
掲載誌名 JOURNAL OF PEDIATRIC SURGERY
出版社・発行元 W B SAUNDERS CO
巻・号・頁 32(1),pp.41-43
著者・共著者 T Sawai,N Usui,K Sando,Y Fukui,S Kamata,A Okada,N Taniguchi,N Itano,K Kimata
概要 Fetal wound healing proceeds without fibrosis or scar formation in contrast to adult wound healing. The mechanisms responsible for this remarkable process are mediated in part through a fetal wound extracellular matrix rich in hyaluronic acid (HA). Polyvinylalcohol sponge (PVA) wound implants were placed pervertebrally at 24 days' gestation in fetal (N = 118) rabbits and in adult (N = 44) rabbits, and then harvested at 1, 2, 3, 4, 5, and 7 days postwounding. To analyze-the fetal and adult wound matrix, the HA concentration of wound fluid within the PVA sponge was quantitated using a-newly developed assay. A significantly increased (P < .05) HA deposition on days 1 through 7 in the fetal wounds was found compared with the adult wound. These observations may suggest an important physiologic role in fetal wound healing by providing a more fluid and malleable matrix. These results, coupled with earlier findings of the lack of an acute inflammatory response in the fetus, further support the hypothesis that fetal response to injury is significantly different from adult response in this prescience of an implanted PVA sponge. Copyright (C) 1997 by W.B. Saunders Company
ISSN 0022-3468