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イタノ ナオキ
ITANO NAOKI
板野 直樹 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 1999/05 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Relationship between hyaluronan production and metastatic potential of mouse mammary carcinoma cells |
| 執筆形態 | その他 |
| 掲載誌名 | CANCER RESEARCH |
| 出版社・発行元 | AMER ASSOC CANCER RESEARCH |
| 巻・号・頁 | 59(10),pp.2499-2504 |
| 著者・共著者 | N Itano,T Sawai,O Miyaishi,K Kimata |
| 概要 | To investigate the roles of hyaluronan produced by cancer cells in cancer metastasis, the metastatic potential of the highly metastatic mouse mammary carcinoma FM3A HA1 cell line was compared with those of hyaluronan-deficient mutant cells. Five different mutant clones showed markedly reduced hyaluronan production and lacked the ability to form hyaluronan-rich pericellular coats. These mutant clones displayed significant decreases in metastatic ability compared with the parental cells after i.v. injection into syngeneic mice. These results suggested that the decreased hyaluronan production caused not only the lack of matrix formation but also decreased metastatic potential of the cancer cells. Expression of mouse hyaluronan synthase 1 (HAS1) by transfection into HAS(-) cells defective in hyaluronan synthase activity rescued hyaluronan matrix formation as well as hyaluronan production, Lung metastasis after i.v, injection of HAS1 transfectants was also recovered significantly. The results provide direct evidence for the involvement of hyaluronan in cancer metastasis. |
| ISSN | 0008-5472 |