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イタノ ナオキ
ITANO NAOKI
板野 直樹 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2002/10 |
| 形態種別 | その他 |
| 査読 | 査読あり |
| 標題 | Mammalian hyaluronan synthases |
| 執筆形態 | その他 |
| 掲載誌名 | IUBMB LIFE |
| 出版社・発行元 | TAYLOR & FRANCIS INC |
| 巻・号・頁 | 54(4),pp.195-199 |
| 著者・共著者 | N Itano,K Kimata |
| 概要 | Three mammalian hyaluronan (HA) synthase genes, HAS1, HAS2, and HAS3, have been cloned and expressed, allowing the mechanisms for regulation of HA biosynthesis and function to be studied. The hyaluronan synthase (HAS) isoforms differ in kinetic characteristics and product size. The expression of each HAS isoform is controlled in a different fashion when mammalian cells are stimulated by various cytokines and the expression patterns are both spatially and temporally regulated during embryonic development. The existence of three different HAS isoforms with different characteristics implies that the broad range of biological and physiological roles performed by HA are regulated by controlling the activities and expression of the HAS isoforms. This review focuses on recent findings on the regulatory mechanisms for controlling HA biosynthesis and provides new insights into the enzymic basis for the functional regulation of HA. |
| DOI | 10.1080/15216540290114478 |
| ISSN | 1521-6543 |