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イタノ ナオキ
ITANO NAOKI
板野 直樹 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2004 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Elevated transcript level of hyaluronan synthase1 gene correlates with poor prognosis of human colon cancer |
| 執筆形態 | その他 |
| 掲載誌名 | CLINICAL & EXPERIMENTAL METASTASIS |
| 出版社・発行元 | KLUWER ACADEMIC PUBL |
| 巻・号・頁 | 21(1),pp.57-63 |
| 著者・共著者 | Y Yamada,N Itano,H Narimatsu,T Kudo,K Morozumi,S Hirohashi,A Ochiai,M Ueda,K Kimata |
| 概要 | Hyaluronan plays important roles in the complex processes of tumor invasion and metastasis. It is now known that three hyaluronan synthase (HAS) isoforms catalyze hyaluronan synthesis, which raises the question of how they are involved in malignant tumor progression. In this study, we examined the correlation between tumor progression and transcriptional levels of three HAS isoforms in specimens of human colon cancers. Tumor tissues from 31 patients with different diagnostic grades were assessed to determine the level of each HAS isoform by real time RT-PCR. The mean expression coefficients for HAS1, HAS2 and HAS3 in the cancerous parts were 0.82-, 0.91- and 1.22-fold, respectively; of those in the noncancerous parts at Dukes' stage A; 1.00-, 0.95- and 1.06-fold, respectively, at stage B; and 1.95-, 1.16- and 1.19-fold, respectively, at stage C. In survival analysis, a significant correlation was observed between poor survival and the HAS1 transcript level. When the ratio of tumor to normal tissue in the HAS1 level was compared with that of the HA receptor transcript level, there was a positive correlation with that of the CD44 variant 6 level at Dukes' stage C. Our current results therefore suggest that HAS1 plays a role in the malignant progression of human colon cancer cells. |
| ISSN | 0262-0898 |