|
イタノ ナオキ
ITANO NAOKI
板野 直樹 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
|
| 言語種別 | 英語 |
| 発行・発表の年月 | 2016/05 |
| 形態種別 | その他 |
| 査読 | 査読あり |
| 標題 | Hyaluronan: A modulator of the tumor microenvironment |
| 執筆形態 | その他 |
| 掲載誌名 | CANCER LETTERS |
| 出版社・発行元 | ELSEVIER IRELAND LTD |
| 巻・号・頁 | 375(1),pp.20-30 |
| 著者・共著者 | Theerawut Chanmee,Pawared Ontong,Naoki Itano |
| 概要 | Tumors are cellular masses formed through dynamic interactions between tumor cells and a mixed population of stromal cells. Crosstalk between oncogenic and adjacent stromal cells contributes to the formation of a "tumor microenvironment" influencing the tumor cell behaviors of proliferation, invasion, and metastatic spread throughout cancer progression. The composition and structure of the tumor microenvironment vary among different types of tumors and are extensively remodeled in close association with tumor advancement. The tumor microenvironment is composed not only of cellular compartments, such as endothelial cells, fibroblasts, inflammatory cells, and immune cells, but also of bioactive substances, including growth factors and the extracellular matrix. Hyaluronan (HA) is a major component of the extracellular matrix, and the degree of HA accumulation is strongly correlated with a poor prognosis in advanced cancer patients. Emerging evidence has suggested that HA creates a specific microenvironment that is favorable for tumor angiogenesis, invasion, and metastasis. This review highlights the prominent roles of HA as a modulator of the tumor microenvironment and addresses the recent advances regarding HA function in cancer stem cell niches. (C) 2016 Elsevier Ireland Ltd. All rights reserved. |
| DOI | 10.1016/j.canlet.2016.02.031 |
| ISSN | 0304-3835/1872-7980 |