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イタノ ナオキ
ITANO NAOKI
板野 直樹 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2004/05 |
| 形態種別 | その他 |
| 査読 | 査読あり |
| 標題 | Abnormal hyaluronan synthesis and cancer progression |
| 執筆形態 | その他 |
| 掲載誌名 | TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY |
| 出版社・発行元 | GAKUSHIN PUBL CO |
| 巻・号・頁 | 16(89),pp.199-210 |
| 著者・共著者 | N Itano |
| 概要 | Hyaluronan is a major extracellular matrix component that is distributed widely in the body and plays a key role in maintaining the structural integrity of tissue. In addition to functioning as a supporting structure, the sugar chain regulates dynamic cellular behavior such as cell proliferation, motility and differentiation by acting on intracellular signaling pathways through interaction with receptors. Hyaluronan has attracted a great deal of attention because abnormal synthesis of this polysaccharide is often associated with cancer progression. Recently, the role of hyaluronan in promoting malignant cell transformation has been investigated in a series of studies in which the expression of the hyaluronan synthase genes were manipulated. This review outlines the close association between hyaluronan synthesis and cancer progression, citing recent findings in studies aimed at elucidating the mechanism of hyaluronan synthesis. I also address the possibility of developing drugs to prevent cancer progression based on the inhibition of hyaluronan synthesis. |
| ISSN | 0915-7352 |