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イタノ ナオキ
ITANO NAOKI
板野 直樹 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2004/07/14 |
| 形態種別 | 論文集（書籍）内論文 |
| 査読 | 査読あり |
| 標題 | Biological Function of SHAP-Hyaluronan Covalent Complex |
| 執筆形態 | その他 |
| 掲載誌名 | Chemistry and Biology of Hyaluronan |
| 出版社・発行元 | Elsevier Inc. |
| 巻・号・頁 | pp.205-222 |
| 著者・共著者 | Lisheng Zhuo,Naoki Itano,Tsunemasa Nonogaki,Li Shen,Jiwen Wu,Hideto Watanabe,Koji Kimata |
| 概要 | This chapter presents an introduction to the formation of the serum-derived hyaluronan-associated protein (SHAP)-hyaluronan complex and the related physiological significance. This chapter discusses its possible roles in pathological processes. The main point is that the association of SHAP changes the properties of hyaluronan. Mass spectrometry revealed a unique protein-glycosaminoglycan linkage in both IαI family molecules and the SHAP-hyaluronan complex, where an ester bond is formed between the carboxyl group of the asparate residue at the C-terminus of the heavy chains/SHAPs, and the C-6 hydroxyl group of an internal N-acetylgalactosamine residue of the bikunin chondroitin sulfate or an N-acetylglucosamine residue of hyaluronan. Based on the similarity of the protein-glycosaminoglycan linkage and the homology of both the N- and C-terminus between the heavy chain and corresponding SHAP, it is concluded that the SHAP-hyaluronan complex is formed via a trans-esterification reaction in which hyaluronan substitutes for bikunin chondroitin sulfate to form the same type of ester bond with the heavy chains, accompanied by the release of the bikunin proteoglycan. |
| DOI | 10.1016/B978-008044382-9/50040-6 |