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イタノ ナオキ
ITANO NAOKI
板野 直樹 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2005/03 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Hyaluronan synthase expression in pleural malignant mesotheliomas |
| 執筆形態 | その他 |
| 掲載誌名 | VIRCHOWS ARCHIV |
| 出版社・発行元 | SPRINGER |
| 巻・号・頁 | 446(3),pp.246-250 |
| 著者・共著者 | N Kanomata,T Yokose,T Kamijo,H Yonou,T Hasebe,N Itano,K Kimata,A Ochiai |
| 概要 | Hyaluronan (HA) is thought to play several important roles in tumor growth, tumorigenicity, and tumor dissemination and metastasis. Recently, three isoforms of hyaluronan synthase (HAS) have been cloned. Our objective was to determine which of the HAS isoforms were expressed in pleural malignant mesotheliomas, the most representative lesion of HA-producing tumors. We studied 10 cases of pleural malignant mesothelioma using novel antibodies of HAS. We compared HAS expression patterns of mesothelioma and pulmonary adenocarcinoma. Immunohistochemically, 9 of 10 (90%) cases of mesothelioma had extensive reaction to anti-HAS1 and anti-HAS2 antibodies, while HAS3 overexpression was present in 4 of 10 cases (40%). Of 20 cases of pulmonary adenocarcinoma, 5 overexpressed HAS1 (25%), 16 of 20 HAS2 (80%), and 4 of 20 HAS3 (20%). The expression level of HAS1 was significantly higher in mesotheliomas than in pulmonary adenocarcinoma (P=0.0036). Our data suggests that HAS1 might be a useful positive marker of malignant mesothelioma. However, a definitive conclusion should be based on further large-scale studies. |
| DOI | 10.1007/s00428-004-1197-8 |
| ISSN | 0945-6317 |