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イタノ ナオキ
ITANO NAOKI
板野 直樹 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2008/05 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Reduction of Calponin h1 expression in human colon cancer blood vessels |
| 執筆形態 | その他 |
| 掲載誌名 | EJSO |
| 出版社・発行元 | ELSEVIER SCI LTD |
| 巻・号・頁 | 34(5),pp.531-537 |
| 著者・共著者 | Y. Yanagisawa,M. Takeoka,T. Ehara,N. Itano,S. Miyagawa,S. Taniguchi |
| 概要 | Aims: Calponin h1 (CN) is a differentiation marker of smooth muscle cells that has been reported to be down-regulated in the blood vessels of several human tumors. In this study, we examined CN expression in blood vessels in relation to the clinical and pathological features of colon cancer tissue samples.
Methods: Fifty-six patients who had undergone colectomy for colon cancer were examined. To assess patients' disease-free survival, those who had metastasis at the time of surgical operation were excluded. Immunohistochemistry was performed by the indirect immunoperoxidase method, using serial sections made from formalin fixed and paraffin embedded tissue blocks. Results: We found that the expression of vascular CN in the peripheral region of colon cancer tissues was significantly reduced in association with tumor progression, lymphatic invasion, vascular invasion and recurrence. This reduction of CN indicated not only a decrease of pericytes and/or smooth muscle cells in tumor vessels, but also the immaturity of those cells, since CN down-regulation occurred even in a smooth muscle actin-positive cells. The down-regulation of CN in vessels in the peripheral region of tumor tissues was inversely associated with the expression of VEGF (vascular endothelial growth factor), seemingly advantageous to angiogenesis. Conclusion: The down-regulation of CN expression in colon cancer vasculature evaluated by immunohistochemistry may be useful in conjunction with conventional staging procedures to predict more reliable outcome and to select therapeutic treatment. (c) 2007 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.ejso.2007.05.010 |
| ISSN | 0748-7983 |