|
ナカムラ ノブヒロ
NAKAMURA NOBUHIRO
中村 暢宏 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
|
| 言語種別 | 英語 |
| 発行・発表の年月 | 1998 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi fragmentation in mitosis |
| 執筆形態 | その他 |
| 掲載誌名 | Cell |
| 出版社・発行元 | CELL PRESS |
| 巻・号・頁 | 94(6),pp.783-793 |
| 著者・共著者 | Lowe, M.,Rabouille, C.,Nakamura, N.,Watson, R.,Jackman, M.,Jämsä, E.,Rahman, D.,Pappin, D.J.C.,Warrenz, G. |
| 概要 | Mitotic fragmentation of the Golgi apparatus can be largely explained by disruption of the interaction between GM130 and the vesicle-docking protein p115. Here we identify a single serine (Ser-25) in GM130 as the key phosphorylated target and Cdc2 as the responsible kinase. MEK1, a component of the MAP kinase signaling pathway recently implicated in mitotic Golgi fragmentation, was not required for GM130 phosphorylation or mitotic fragmentation either in vitro or in vivo. We propose that Cdc2 is directly involved in mitotic Golgi fragmentation and that signaling via MEK1 is not required for this process. |
| DOI | 10.1016/S0092-8674(00)81737-7 |
| ISSN | 0092-8674 |
| Put Code(ORCID) | 19809422 |