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ナカムラ ノブヒロ
NAKAMURA NOBUHIRO
中村 暢宏 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2003 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Identification of a five-pass transmembrane protein family localizing in the Golgi apparatus and the ER |
| 執筆形態 | その他 |
| 掲載誌名 | Biochemical and Biophysical Research Communications |
| 出版社・発行元 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 巻・号・頁 | 312(3),pp.850-857 |
| 著者・共著者 | Shakoori, A.,Fujii, G.,Yoshimura, S.-I.,Kitamura, M.,Nakayama, K.,Ito, T.,Ohno, H.,Nakamura, N. |
| 概要 | A family of five-pass transmembrane proteins (FinGERs) were identified from the protein sequence database. The family includes yeast Yip1p, Yip4p Yip5p, and Yif1p, and also their plant, insects, nematode, and mammalian homologues, suggesting their conserved function in a broad range of species. Eight family members were found in human. Multiple sequence alignment revealed three regions conserved among all family members. All of the human family members were expressed widely in various tissues. The human proteins were localized in and around the Golgi apparatus and may also be in the ER to some extent. The Golgi apparatus was fragmented by overexpression of the five of the family members. Some of the members were found to interact by yeast two-hybrid analysis, suggesting the formation of a complex. These results suggest that FinGERs function in maintenance of the Golgi structure and/or transport between the ER and the Golgi apparatus. (C) 2003 Elsevier Inc. All rights reserved. |
| DOI | 10.1016/j.bbrc.2003.10.197 |
| ISSN | 0006-291X |
| Put Code(ORCID) | 19809414 |