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ナカムラ ノブヒロ
NAKAMURA NOBUHIRO
中村 暢宏 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2008 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Myt1 protein kinase is essential for Golgi and ER assembly during mitotic exit |
| 執筆形態 | その他 |
| 掲載誌名 | Journal of Cell Biology |
| 出版社・発行元 | ROCKEFELLER UNIV PRESS |
| 巻・号・頁 | 181(1),pp.89-103 |
| 著者・共著者 | Nakajima, H.,Yonemura, S.,Murata, M.,Nakamura, N.,Piwnica-Worms, H.,Nishida, E. |
| 概要 | Myt1 was originally identified as an inhibitory kinase for Cdc2 (Cdk1), the master engine of mitosis, and has been thought to function, together with Wee1, as a negative regulator of mitotic entry. In this study, we report an unexpected finding that Myt1 is essential for Golgi and endoplasmic reticulum (ER) assembly during telophase in mammalian cells. Our analyses reveal that both cyclin B1 and cyclin B2 serve as targets of Myt1 for proper Golgi and ER assembly to occur. Thus, our results show that Myt1-mediated suppression of Cdc2 activity is not indispensable for the regulation of a broad range of mitotic events but is specifically required for the control of intracellular membrane dynamics during mitosis. |
| DOI | 10.1083/jcb.200708176 |
| ISSN | 0021-9525 |
| Put Code(ORCID) | 19809402 |