ナカムラ ノブヒロ   NAKAMURA NOBUHIRO
  中村 暢宏
   所属   京都産業大学  生命科学部 先端生命科学科
   職種   教授
言語種別 英語
発行・発表の年月 2010/03/19
形態種別 研究論文
査読 査読あり
標題 Emerging new roles of GM130, a cis-Golgi matrix protein, in higher order cell functions
執筆形態 その他
掲載誌名 Journal of Pharmacological Sciences
巻・号・頁 112(3),pp.255-264
著者・共著者 Nobuhiro Nakamura
概要 GM130 is a peripheral membrane protein strongly attached to the Golgi membrane and is isolated from the detergent and salt resistant Golgi matrix. GM130 is rich in coiled-coil structures and predicted to take a rod-like shape. Together with p115, giantin, and GRASP65, GM130 facilitates vesicle fusion to the Golgi membrane as a vesicle "tethering factor". GM130 is also involved in the maintenance of the Golgi structure and plays a major role in the disassembly and reassembly of the Golgi apparatus during mitosis. Emerging evidence suggests that GM130 is involved in the control of glycosylation, cell cycle progression, and higher order cell functions such as cell polarization and directed cell migration. This creates the potential for novel Golgi-targeted drugs and treatments for various diseases including glycosylation defects, immune diseases, and cancer. © 2010 The Japanese Pharmacological Society.
DOI 10.1254/jphs.09R03CR
ISSN 1347-8613
PMID 20197635
Put Code(ORCID) 19809391