ハマノ　ツヨシ   HAMANO TSUYOSHI
  濱野　強
   所属   京都産業大学  現代社会学部 健康スポーツ社会学科
   職種   教授
言語種別 英語
発行・発表の年月 2016/02
形態種別 研究論文
査読 査読あり
標題 Effect of Serum Cholesterol on Insulin Secretory Capacity: Shimane CoHRE Study
執筆形態 その他
掲載誌名 PLOS ONE
出版社・発行元 PUBLIC LIBRARY SCIENCE
巻・号・頁 11(2),pp.e0149452
著者・共著者 Masayuki Wada,Shozo Yano,Tsuyoshi Hamano,Toru Nabika,Shunichi Kumakura
概要 Objectives
Previous studies indicate that, in addition to the blood glucose level, the lipid level in the blood may affect functions of pancreatic beta cells. In this study, we aimed to examine whether there was a relationship between the serum level of total cholesterol (TC) and the insulin secretory capacity in healthy subjects.
Subjects and Methods
In participants of health examinations conducted from 2006 to 2010, we analyzed data from a total of 2,499 subjects (1,057 men and 1,442 women) after exclusion of individuals with dyslipidemia, thyroid dysfunction, diabetes, HbA1c >= 6.5%, or fasting blood glucose >= 126 mg/dL. Homeostasis model assessment for beta cell function (HOMA-beta) was utilized as a model representing the pancreatic beta cell function.
Results
Although the serum TC level had a positive correlation with HOMA-beta in a univariate correlation analysis, after adjustment by confounding factors in a multiple regression analysis, HOMA-beta had a negative correlation with TC. This was further confirmed in a multiple logistic regression analysis, showing that higher TC was an independent risk factor for decreased insulin secretory capacity (defined as HOMA-beta >= 30%) together with higher age, lower BMI, lower TG, male sex and regular alcohol intake. After the participants were stratified by BMI into three groups, the effect of TC on HOMA-beta increased along with the increase in BMI, and it was highly significant in the highest tertile.
Conclusion
This cross-sectional study indicated that increased serum TC level might be related to the decrease of insulin secretory capacity in aged healthy population and that reduction of TC is more necessary in obese subjects to prevent diabetes.
DOI 10.1371/journal.pone.0149452
ISSN 1932-6203