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エンドウ トシヤ
ENDO TOSHIYA
遠藤 斗志也 所属 京都産業大学 生命科学部 先端生命科学科 職種 客員教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2009/01 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Tim23-Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import |
| 執筆形態 | その他 |
| 掲載誌名 | JOURNAL OF CELL BIOLOGY |
| 出版社・発行元 | ROCKEFELLER UNIV PRESS |
| 巻・号・頁 | 184(1),pp.129-141 |
| 著者・共著者 | Yasushi Tamura,Yoshihiro Harada,Takuya Shiota,Koji Yamano,Kazuaki Watanabe,Mihoko Yokota,Hayashi Yamamoto,Hiromi Sesaki,Toshiya Endo |
| 概要 | Mitochondrial protein traffic requires coordinated operation of protein translocator complexes in the mitochondrial membrane. The TIM23 complex translocates and inserts proteins into the mitochondrial inner membrane. Here we analyze the intermembrane space (IMS) domains of Tim23 and Tim50, which are essential subunits of the TIM23 complex, in these functions. We find that interactions of Tim23 and Tim50 in the IMS facilitate transfer of precursor proteins from the TOM40 complex, a general protein translocator in the outer membrane, to the TIM23 complex. Tim23-Tim50 interactions also facilitate a late step of protein translocation across the inner membrane by promoting motor functions of mitochondrial Hsp70 in the matrix. Therefore, the Tim23- Tim50 pair coordinates the actions of the TOM40 and TIM23 complexes together with motor proteins for mitochondrial protein import. |
| DOI | 10.1083/jcb.200808068 |
| ISSN | 0021-9525 |