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イタノ ナオキ
ITANO NAOKI
板野 直樹 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 1997/01 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Hyaluronic acid of wound fluid in adult and fetal rabbits |
| 執筆形態 | その他 |
| 掲載誌名 | JOURNAL OF PEDIATRIC SURGERY |
| 出版社・発行元 | W B SAUNDERS CO |
| 巻・号・頁 | 32(1),pp.41-43 |
| 著者・共著者 | T Sawai,N Usui,K Sando,Y Fukui,S Kamata,A Okada,N Taniguchi,N Itano,K Kimata |
| 概要 | Fetal wound healing proceeds without fibrosis or scar formation in contrast to adult wound healing. The mechanisms responsible for this remarkable process are mediated in part through a fetal wound extracellular matrix rich in hyaluronic acid (HA). Polyvinylalcohol sponge (PVA) wound implants were placed pervertebrally at 24 days' gestation in fetal (N = 118) rabbits and in adult (N = 44) rabbits, and then harvested at 1, 2, 3, 4, 5, and 7 days postwounding. To analyze-the fetal and adult wound matrix, the HA concentration of wound fluid within the PVA sponge was quantitated using a-newly developed assay. A significantly increased (P < .05) HA deposition on days 1 through 7 in the fetal wounds was found compared with the adult wound. These observations may suggest an important physiologic role in fetal wound healing by providing a more fluid and malleable matrix. These results, coupled with earlier findings of the lack of an acute inflammatory response in the fetus, further support the hypothesis that fetal response to injury is significantly different from adult response in this prescience of an implanted PVA sponge. Copyright (C) 1997 by W.B. Saunders Company |
| ISSN | 0022-3468 |