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イタノ ナオキ
ITANO NAOKI
板野 直樹 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 1997/05 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Chromosomal localization of the human and mouse hyaluronan synthase genes |
| 執筆形態 | その他 |
| 掲載誌名 | GENOMICS |
| 出版社・発行元 | ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS |
| 巻・号・頁 | 41(3),pp.493-497 |
| 著者・共著者 | AP Spicer,MF Seldin,AS Olsen,N Brown,DE Wells,NA Doggett,N Itano,K Kimata,J Inazawa,JA McDonald |
| 概要 | We have recently identified a new vertebrate gene family encoding putative hyaluronan (HA) synthases. Three highly conserved related genes have been identified, designated HAS1, HAS2, and HAS3 in humans and Has1, Has2, and Has3 in the mouse, All three genes encode predicted plasma membrane proteins with multiple transmembrane domains and approximately 25% amino acid sequence identity to the Streptococcus pyogenes HA synthase, HasA. Furthermore, expression of any one AAS gene in transfected mammalian cells leads to high levels of HA biosynthesis. We now report the chromosomal localization of the three HAS genes in human and in mouse. The genes localized to three different positions within both the human and the mouse genomes. HAS1 was localized to the human chromosome 19q13.3-q13.4 boundary and Has1 to mouse Chr 17. HAS2 was localized to human chromosome 8q24.12 and Has2 to mouse Chr 15. HAS3 was localized to human chromosome 16q22.1 and Has3 to mouse Chr 8, The map position for HAS1 reinforces the recently reported relationship between a small region of human chromosome 19q and proximal mouse chromosome 17, HAS2 mapped outside the predicted critical region delineated for the Langer-Giedion syndrome and can thus be excluded as a candidate gene for this genetic syndrome. (C) 1997 Academic Press. |
| ISSN | 0888-7543 |