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エンドウ トシヤ
ENDO TOSHIYA
遠藤 斗志也 所属 京都産業大学 生命科学部 先端生命科学科 職種 客員教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2010/06 |
| 形態種別 | その他 |
| 査読 | 査読あり |
| 標題 | Transport of proteins across or into the mitochondrial outer membrane |
| 執筆形態 | その他 |
| 掲載誌名 | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH |
| 出版社・発行元 | ELSEVIER SCIENCE BV |
| 巻・号・頁 | 1803(6),pp.706-714 |
| 著者・共著者 | Toshiya Endo,Koji Yamano |
| 概要 | Mitochondria are surrounded by two biological membranes. The outer mitochondrial membrane contains two major translocators, the TOM40 (TOM) and TOB/SAM complexes for protein translocation across and/or insertion into the outer membrane. The TOM40 complex functions as an entry gate for most mitochondrial proteins, and the TOB/SAM complex as a specialized insertion machinery for beta-barrel membrane proteins In order to handle loosely folded or unfolded precursor polypepndes, those translocators cooperate with chaperones in the cytosol and intermembrane space, and also exhibit chaperone-like functions on their own Several a-helical membrane proteins take 'non-standard' routes to be inserted into the outer membrane. Here we review the current view on a remarkable variety of mechanisms of protein transport taking place at the mitochondrial outer membrane (C) 2009 Elsevier B.V All rights reserved |
| DOI | 10.1016/j.bbamcr.2009.11.007 |
| ISSN | 0167-4889 |