|
イタノ ナオキ
ITANO NAOKI
板野 直樹 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
|
| 言語種別 | 英語 |
| 発行・発表の年月 | 1999/09 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Receptor for hyaluronan-mediated motility and CD44 expressions in colon cancer assessed by quantitative analysis using real-time reverse transcriptase-polymerase chain reaction |
| 執筆形態 | その他 |
| 掲載誌名 | JAPANESE JOURNAL OF CANCER RESEARCH |
| 出版社・発行元 | ELSEVIER SCI IRELAND LTD |
| 巻・号・頁 | 90(9),pp.987-992 |
| 著者・共著者 | Y Yamada,N Itano,H Narimatsu,T Kudo,S Hirohashi,A Ochiai,A Niimi,M Ueda,K Kimata |
| 概要 | Receptor for hyaluronan (HA)-mediated motility (RHAMM) is a receptor for HA-mediated motility and its expression is correlated with malignancy of ras-transformed cells in that binding of HA to this receptor activates their migratory ability. CD44, a cell surface receptor for HA is also implicated in metastatic behavior of some cancer cells, In this study we examined the relationships of cancer progression with mRNA levels of RHAMM, CD44 (all forms), and exon 6 of CD44 using the real-time reverse transcriptase-polymerase chain reaction method in specimens of colon cancers at different diagnostic stages from 30 patients. Increased mRNA levels of RHAMM were observed in 29 specimens (97%), CD44s (all forms) in 21 specimens (70%), and its exon 6 in 19 specimens (63%) in comparison with those in the corresponding noncancerous tissue specimens. A statistically significant correlation between RHAMM expression and cancerous specimens at any of Dukes' stages A, B, and C was found, and the overexpression of CD44 mRNAs was confirmed in specimens at Dukes' stage C, Thus, our present study for the first time suggests that RHAMM expression may be a clinically useful indicator of colon cancer. |
| ISSN | 0910-5050 |