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エンドウ トシヤ
ENDO TOSHIYA
遠藤 斗志也 所属 京都産業大学 生命科学部 先端生命科学科 職種 客員教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2020/05/26 |
| 形態種別 | 研究論文 |
| 標題 | Lipid homeostasis in mitochondria. |
| 執筆形態 | その他 |
| 掲載誌名 | Biological chemistry |
| 掲載区分 | 国外 |
| 巻・号・頁 | 401(6-7),pp.821-833 |
| 著者・共著者 | Yasushi Tamura,Shin Kawano,Toshiya Endo |
| 概要 | Mitochondria are surrounded by the two membranes, the outer and inner membranes, whose lipid compositions are optimized for proper functions and structural organizations of mitochondria. Although a part of mitochondrial lipids including their characteristic lipids, phosphatidylethanolamine and cardiolipin, are synthesized within mitochondria, their precursor lipids and other lipids are transported from other organelles, mainly the ER. Mitochondrially synthesized lipids are re-distributed within mitochondria and to other organelles, as well. Recent studies pointed to the important roles of inter-organelle contact sites in lipid trafficking between different organelle membranes. Identification of Ups/PRELI proteins as lipid transfer proteins shuttling between the mitochondrial outer and inner membranes established a part of the molecular and structural basis of the still elusive intra-mitochondrial lipid trafficking. |
| DOI | 10.1515/hsz-2020-0121 |
| PMID | 32229651 |