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ハマノ ツヨシ
HAMANO TSUYOSHI
濱野 強 所属 京都産業大学 現代社会学部 健康スポーツ社会学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2014 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | MC4R rs17782313 gene polymorphism was associated with glycated hemoglobin independently of its effect on BMI in Japanese: the Shimane COHRE study |
| 執筆形態 | その他 |
| 掲載誌名 | ENDOCRINE RESEARCH |
| 出版社・発行元 | INFORMA HEALTHCARE |
| 巻・号・頁 | 39(3),pp.115-119 |
| 著者・共著者 | Paulin Beya Wa Bitadi Mutombo,Masayuki Yamasaki,Tsuyoshi Hamano,Minoru Isomura,Toru Nabika,Kuninori Shiwaku |
| 概要 | Background: Type 2 diabetes (T2D) is among the leading public health problems in Japan, and glycated hemoglobin (HbA1c) can be used to screen the population for T2D. Gene polymorphisms, known to be associated with obesity, may predispose individuals to T2D. Rs17782313 the melanocortin 4 receptor (MC4R) has shown one of the strongest associations with body mass index (BMI). We conducted a study to investigate whether rs17782313 (TT versus TC + CC) was associated with HbA1c. Method: We conducted a cross-sectional study including 1142 Japanese adults (446 men: 64.9 +/- 14.4 years and 696 women: 66.7 +/- 12.3 years). MC4R rs17782313 was genotyped using fast real-time polymerase chain reaction. Results: TC + CC genotype group showed significantly greater BMI (p = 0.039) and HbA1c (p = 0.001) than TT genotype group after adjustment for gender, age and, for HbA1c, BMI. Further analysis using linear regression analysis confirmed that the effect of MC4R rs17782313 on HbA1c (beta = 0.08; p = 0.003) was independent of the effect age, gender, BMI, low density lipoprotein cholesterol, homeostasis model assessment of insulin resistance and of beta cell function. This significant independent association was similarly noticed in non-obese (beta = 2.82; p = 0.005) subgroups. Conclusion: MC4R rs17782313 was associated with obesity and could confer a certain susceptibility to T2D that could be independent of its pro-obesity effect. |
| DOI | 10.3109/07435800.2013.844163 |
| ISSN | 0743-5800/1532-4206 |