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カトウ ケイコ
KATO KEIKO
加藤 啓子 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 1998/06 |
| 形態種別 | その他 |
| 標題 | Expression of neuropsin in the keratinizing epithelial tissue - Immunohistochemical analysis of wild-type and nude mice |
| 執筆形態 | その他 |
| 掲載誌名 | JOURNAL OF INVESTIGATIVE DERMATOLOGY |
| 出版社・発行元 | BLACKWELL SCIENCE INC |
| 巻・号・頁 | 110(6),pp.923-931 |
| 著者・共著者 | N Inoue,K Kuwae,A Ishida-Yamamoto,H Iizuka,M Shibata,S Yoshida,K Kato,S Shiosaka |
| 概要 | Neuropsin serine protease that was first cloned from the mouse brain as a factor related to neural plasticity. Subsequent in situ hybridization histochemical analysis indicated a broad localization of its mRNA throughout the whole body, although the details remain obscure, In this study, we showed that neuropsin immunoreactivity is localized in the keratinized stratified epithelia of the mouse epidermis, hair, tongue, palate, nasal cavity, pharynges, esophagus, and forestomach. In the skin and mucous membranes, neuropsin immunoreactivity was found in the stratum spinosum and the stratum granulosum. The immunoreactivity in the former sublayer was mainly present in the cytoplasm, but that in the latter sublayer was exclusively present in the intercellular space or on the outer surface is of the cell membrane and thus exhibited a lamellar-like peripheral distribution. During development, the appearance of neuropsin immunoreactivity in the various epithelia was found at embryonic days 14.5-15.5, prior to formation of the stratum corneum, More extensive expression of neuropsin immunoreactivity was found in the nude mouse skin and mucous membranes than in wild-type mice. Because the nude mouse is characterized by genetic impairment of keratinization, such abnormal neuropsin expression might be caused or affected by this impairment. Therefore, neuropsin, an extracellular serine protease, is suggested to be involved in keratinization in the stratified epithelia. |
| DOI | 10.1046/j.1523-1747.1998.00212.x |
| ISSN | 0022-202X |