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イタノ ナオキ
ITANO NAOKI
板野 直樹 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2003/11 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | CD44 variant exon 6 expressions in colon cancer assessed by quantitative analysis using real time reverse transcriptase-polymerase chain reaction |
| 執筆形態 | その他 |
| 掲載誌名 | ONCOLOGY REPORTS |
| 出版社・発行元 | PROFESSOR D A SPANDIDOS |
| 巻・号・頁 | 10(6),pp.1919-1924 |
| 著者・共著者 | Y Yamada,N Itano,H Narimatsu,T Kudo,S Hirohashi,A Ochiai,Tohnai, I,M Ueda,K Kimata |
| 概要 | CD44 is a family of transmembrane glycoproteins that serve as a major receptor for hyaluronate and the splice variants play a very important role in tumor progression and metastasis. We examined the relationship between cancer progression and mRNA levels of CD44 variant exon 6 (CD44v6) in specimens of colon cancer at different diagnostic stages from 31 patients using real time RT-PCR analysis. Increased mRNA levels of CD44v6 were observed in 82% of the specimens in comparison with those in the corresponding non-cancerous tissue specimens. A statistically significant correlation between the CD44v6 expression and the cancerous state was found in most specimens at all Dukes stages. None of the other parameters were related to the expression in the cancerous specimens. Quantitative real time RT-PCR analysis showed that there was no correlation of CD44v6 expression with tumor progression, although CD44v6 is upregulated in transformation. Thus, CD44v6 expression may be a clinically useful indicator of colon cancer. |
| ISSN | 1021-335X |