ハマノ　ツヨシ   HAMANO TSUYOSHI
  濱野　強
   所属   京都産業大学  現代社会学部 健康スポーツ社会学科
   職種   教授
言語種別 英語
発行・発表の年月 2015/09
形態種別 研究論文
査読 査読あり
標題 Interrelationship between glucose metabolism and undercarboxylated osteocalcin: a cross-sectional study in a community-dwelling population
執筆形態 その他
掲載誌名 ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
出版社・発行元 H E C PRESS, HEALTHY EATING CLUB PTY LTD
巻・号・頁 24(3),pp.489-495
著者・共著者 Shozo Yano,Toru Nabika,Atsushi Nagai,Tsuyoshi Hamano,Masayuki Yamasaki,Minoru Isomura,Kuninori Shiwaku,Shuhei Yamaguchi,Toru Yamaguchi,Toshitsugu Sugimoto
概要 Objective: Undercarboxylated osteocalcin (ucOC) produced from the bone was recently found to play a regulatory role in the insulin and adiponectin secretion. We performed a cross-sectional study to investigate the relationship between ucOC and diabetes mellitus (DM). Methods: We included 1,870 subjects aged over 50 from participants of a health examination. According to the current medication and past history, 605 subjects had hypertension (HT), 316 had dyslipidemia (DL), and 182 had type 2 DM. Fasting blood samples were collected to measure concentrations of ucOC and the bone turnover marker, tartrate-resistant acid phosphatase 5b (TRACP5b) by ELISA. Results: The serum ucOC level was significantly lower in DM(+) than DM(-) in both men and women. In a logistic regression analysis, a low level of ucOC was significantly associated with the presence of DM in both men and women after adjusting for age, BMI, serum creatinine, triglyceride, and TRACP5b. Multiple regression analysis showed a negative association of ucOC with HbA1c and fasting plasma glucose, and a positive association with the insulin level. In contrast, no association was found between TRACP5b and the indices above, suggesting that the effect of ucOC on the insulin secretion and the glycemic status was independent of bone turnover. Conclusions: The present cross-sectional study showed a significant association between ucOC and glucose metabolism after correction with bone turnover in a community-dwelling population both in men and women, indicating that ucOC may play an important role in the pathogenesis of DM through the pathways independent of bone metabolism.
DOI 10.6133/apjcn.2015.24.4.02
ISSN 0964-7058