|
ハマノ ツヨシ
HAMANO TSUYOSHI
濱野 強 所属 京都産業大学 現代社会学部 健康スポーツ社会学科 職種 教授 |
|
| 言語種別 | 英語 |
| 発行・発表の年月 | 2015/10 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Relationship between Blood Myostatin Levels and Kidney Function: Shimane CoHRE Study |
| 執筆形態 | その他 |
| 掲載誌名 | PLOS ONE |
| 出版社・発行元 | PUBLIC LIBRARY SCIENCE |
| 巻・号・頁 | 10(10),pp.e0141035 |
| 著者・共著者 | Shozo Yano,Atsushi Nagai,Minoru Isomura,Masayuki Yamasaki,Tsunetaka Kijima,Miwako Takeda,Tsuyoshi Hamano,Toru Nabika |
| 概要 | Objectives
Myostatin (MSTN), a member of TGF-beta superfamily, is produced in the skeletal muscle to inhibit myocyte differentiation. MSTN expression is increased in the skeletal muscle in patients with chronic kidney disease (CKD), which may play a role in the pathogenesis of sarcopenia or in the protein energy wasting (PEW). This observation implies that the plasma MSTN level may be correlated with kidney function. Thus, we conducted a cross-sectional study to evaluate the association between the plasma MSTN concentration and the estimated glomerular filtration rate (eGFR). Subjects and Methods Subjects were 781 participants of a health examination performed in a rural area in Japan. Among them, 124 subjects were selected by stratified random sampling according to eGFR. Creatinine clearance (ClCr) by the Cockcroft-Gault equation was used as a measure of kidney function. Plasma concentration of MSTN was determined by ELISA. Results The plasma MSTN level was not different between men (3.42 +/- 1.61 ng/mL) and women (3.27 +/- 1.43 ng/mL). In a simple regression analysis, the MSTN level was significantly correlated with eGFR (r = -0.25, p<0.01) and ClCr (r = -0.20, p<0.05) but not with age and BMI. In a multiple linear regression analysis, the MSTN level showed a negative correlation with eGFR (standardized beta = -0.31, p<0.01) and ClCr (standardized beta = -0.35, p<0.01) under the adjustment with age, sex, BMI and LDL-C. Weak correlation was observed between the MSTN level and BMI / the serum LDL-C level. When the subjects were stratified into 4 groups according to eGFR, MSTN was significantly greater in the groups with the lowest and the 2nd lowest eGFR (3.55 +/- 1.79 and 3.76 +/- 1.75 ng/mL, respectively) than the level in the group with the highest eGFR (2.77 +/- 0.85 ng/mL). Conclusion Plasma MSTN level was elevated in an early stage of CKD, which could be involved in the progression of sarcopenia. |
| DOI | 10.1371/journal.pone.0141035 |
| ISSN | 1932-6203 |