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イタノ ナオキ
ITANO NAOKI
板野 直樹 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2005/06 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Role of hyaluronan and hyaluronan synthase in endometrial cancer |
| 執筆形態 | その他 |
| 掲載誌名 | ONCOLOGY REPORTS |
| 出版社・発行元 | PROFESSOR D A SPANDIDOS |
| 巻・号・頁 | 13(6),pp.1101-1105 |
| 著者・共著者 | H Yabushita,T Kishida,K Fusano,K Kanyama,LS Zhuo,N Itano,K Kimata,M Noguchi |
| 概要 | The aim of this study was to determine if the immunohistochemical expression of hyaluronan synthase (HAS) and serum levels of hyaluronan correlate with the clinicopathological manifestations of endometrial carcinoma. Sera were obtained from 59 endometrial cancer patients and 22 post-menopausal healthy women. Concentration of hyaluronan in sera was measured by an inhibitory ELISA using a hyaluronan-binding protein. Tissues obtained from 59 endometrial cancer patients were immunostained by the avid i n-bi oti n-peroxidase complex method using anti-HAS1, anti-HAS2, anti-HAS3 and anti-CD44 antibody. A section was defined as having positive expression when >50% of the tumor cells were intensely stained. The expression of HASI was related to the depth of myornetrial invasion, histological,grade and lymph-vascular space involvement, but the expression of HAS2 and HAS3 was unrelated to these parameters. CD44 expression occurred more frequently in the HAS2- or HAS3-positive groups than in the HAS2- or HAS3-negative groups, and the expression of HASI was unrelated to CD44 expression. Serum levels of hyaluronan were higher in the endometrial cancer group than in the healthy control group, and increased with depth of myometrial invasion, histological grade and lymph-vascular space involvement. Serum hyaluronan levels were higher in the HASI-positive group than in the HASI-negative group, but the expression of HAS2 and HAS3 was unrelated to serum hyaluronan levels. HAS1 expression and an increase in serum hyaluronan in endometrial cancer may be associated with disease progression through myometrial invasion and lymph-vascular space involvement. |
| ISSN | 1021-335X |